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aav-vector-design-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
AAV vector design: capsid selection, promoter optimization, payload capacity.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/aav-vector-design-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The AAV Vector Design Agent provides AI-driven design of adeno-associated virus vectors for gene therapy applications. It covers capsid selection and engineering, promoter/enhancer design, transgene optimization, and manufacturing considerations.
- When selecting optimal AAV serotype for tissue-specific targeting.
- To design novel capsid variants with enhanced properties.
- For optimizing transgene expression cassettes.
- When predicting immunogenicity and neutralizing antibody escape.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Capsid Selection: Match AAV serotype to target tissue based on tropism profiles.
-
Capsid Engineering: Design modified capsids for enhanced transduction or immune evasion.
-
Promoter Design: Select and optimize tissue-specific or ubiquitous promoters.
-
Transgene Optimization: Codon optimization and regulatory element design.
-
Immunogenicity Prediction: Predict NAb binding and T-cell epitopes.
-
Manufacturing Assessment: Evaluate producibility and purification considerations.
AAV Serotype Tropism
| Serotype | Primary Tropism | Clinical Use |
|---|---|---|
| AAV1 | Muscle, CNS | Glybera (muscle) |
| AAV2 | Broad (liver, muscle) | Luxturna (retina) |
| AAV5 | CNS, liver, retina | Hemgenix (liver) |
| AAV8 | Liver, muscle | Multiple trials |
| AAV9 | CNS, cardiac, liver | Zolgensma (CNS) |
| AAVrh10 | CNS, liver | CNS trials |
| AAVrh74 | Muscle | Elevidys (muscle) |
| AAV-PHP.eB | CNS (mouse) | Research |
Workflow
-
Input: Target tissue, therapeutic gene, patient population characteristics.
-
Capsid Selection: Rank serotypes by tropism profile match.
-
Capsid Engineering: Design modifications if needed (peptide insertion, point mutations).
-
Cassette Design: Optimize ITR-to-ITR expression cassette.
-
Immunogenicity Analysis: Predict NAb prevalence and T-cell epitopes.
-
Manufacturing Review: Assess production feasibility.
-
Output: Complete vector design with rationale.
Use cases
- When selecting optimal AAV serotype for tissue-specific targeting.
- To design novel capsid variants with enhanced properties.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- CRISPR_Design_Agent - For gene editing payloads
- Protein_Engineering - For capsid design
- RNA_Therapeutics - For alternative modalities
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