Data & ReproProtein Structure & DesignFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction
AL

alphafold

Maintainer FreedomIntelligence · Last updated April 1, 2026

Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-….

OpenClawNanoClawAnalysisReproductionalphafold🔬 omics & computational biologyprotein structure & designvalidate

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/alphafold

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • First time? See Installation Guide to set up Modal and biomodals.

Source Doc

Excerpt From SKILL.md

Option 1: ColabFold (recommended for multimer)

GPU: A100 (40GB) | Timeout: 3600s default

Key parameters

ParameterDefaultOptionsDescription
--model_presetmonomermonomer/multimerModel type
--num_recycle31-20Recycling iterations
--max_template_date-YYYY-MM-DDTemplate cutoff
--use_templatesTrueTrue/FalseUse template search

Successful run

What good output looks like:

  • pLDDT: > 85 (mean, on 0-100 scale) or > 0.85 (normalized)
  • pTM: > 0.70
  • ipTM: > 0.50 for complexes
  • PAE_interface: < 10

Use cases

  • Use alphafold in research workflows aligned with this subject area.
  • Follow the upstream documentation for the full working procedure.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

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