Arboreto

Quick Start

Install arboreto:

Basic GRN inference:

Critical: Always use if __name__ == '__main__': guard because Dask spawns new processes.

1. Basic GRN Inference

For standard GRN inference workflows including:

• Input data preparation (Pandas DataFrame or NumPy array)
• Running inference with GRNBoost2 or GENIE3
• Filtering by transcription factors
• Output format and interpretation

See: references/basic_inference.md

Use the ready-to-run script: scripts/basic_grn_inference.py for standard inference tasks:

2. Algorithm Selection

Arboreto provides two algorithms:

GRNBoost2 (Recommended):

• Fast gradient boosting-based inference
• Optimized for large datasets (10k+ observations)
• Default choice for most analyses

GENIE3:

• Random Forest-based inference
• Original multiple regression approach
• Use for comparison or validation

Quick comparison:

from arboreto.algo import grnboost2, genie3