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armored-cart-design-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Design armored CAR-T cells with cytokine payloads and resistance mechanisms.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/armored-cart-design-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The Armored CAR-T Design Agent provides AI-assisted design of next-generation armored CAR-T cells engineered to express cytokines, chemokines, or other enhancing factors. These armored T cells overcome solid tumor challenges including immunosuppressive TME, poor trafficking, and T cell exhaustion, with recent clinical success in lymphoma (IL-18) and ongoing trials with IL-12, IL-15, and IL-7.
- When designing CAR-T cells for solid tumor applications.
- For selecting optimal armoring payloads (cytokines, chemokines).
- To optimize cytokine expression levels and regulation.
- When engineering safety switches for armored constructs.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Armoring Payload Selection: Choose optimal cytokines for tumor type.
-
Expression Level Optimization: Balance efficacy vs toxicity.
-
Inducible System Design: Engineer regulated expression systems.
-
Safety Switch Integration: Design kill switches and controls.
-
Construct Optimization: Optimize transgene configuration.
-
Efficacy Prediction: Predict enhanced tumor killing.
Armoring Strategies
| Cytokine | Mechanism | Clinical Status | Tumor Types |
|---|---|---|---|
| IL-12 | Th1 polarization, IFN-gamma | Phase I/II | Solid tumors |
| IL-15 | T/NK persistence | Phase I/II | Hematologic, solid |
| IL-18 | Inflammasome, IFN-gamma | Phase I (promising) | Lymphoma |
| IL-7 | T cell survival | Phase I | Multiple |
| IL-21 | T cell proliferation | Preclinical | Multiple |
| CCL19/21 | T cell trafficking | Preclinical | Solid tumors |
Construct Architecture Options
| Component | Options | Consideration |
|---|---|---|
| Promoter | EF1a, PGK, CAG, NFAT-inducible | Expression level/timing |
| Signal Peptide | Native, IL-2ss, IgK | Secretion efficiency |
| Cytokine | Membrane-bound vs secreted | Local vs systemic |
| Linker | T2A, P2A, IRES | Co-expression efficiency |
| Kill Switch | iCasp9, HSV-TK, CD20 | Safety control |
| Position | Before/after CAR | Expression balance |
Use cases
- When designing CAR-T cells for solid tumor applications.
- For selecting optimal armoring payloads (cytokines, chemokines).
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- CART_Design_Optimizer_Agent - Base CAR optimization
- NK_Cell_Therapy_Agent - NK cell engineering
- Cytokine_Storm_Analysis_Agent - Safety analysis
- TCell_Exhaustion_Analysis_Agent - Exhaustion prevention
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