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bio-alignment-validation

Maintainer FreedomIntelligence · Last updated April 1, 2026

Validate alignment file integrity and detect truncated/corrupt files.

OpenClawNanoClawAnalysisReproductionbio-alignment-validation🧠 bioos extended suitebioos extended bioinformatics suitevalidate

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-alignment-validation

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • Post-alignment quality control to verify alignment quality and identify issues.
  • Insert size should match library preparation protocol.

Source Doc

Excerpt From SKILL.md

Expected Insert Sizes

Library TypeExpected Size
Standard WGS300-500 bp
PCR-free350-550 bp
RNA-seq150-300 bp
ChIP-seq150-300 bp
ATAC-seqMultimodal

Proper Pairing Rate

Percentage of reads correctly paired.

Expected Rates

MetricGoodMarginalPoor
Proper pair> 90%80-90%< 80%
Mapped> 95%90-95%< 90%
Singletons< 5%5-10%> 10%

Use cases

  • Use bio-alignment-validation for genomics and bioinformatics workflows.
  • Apply bio-alignment-validation to sequencing, variant, or omics analysis tasks.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

  • bam-statistics - Basic flagstat and depth
  • duplicate-handling - Mark/remove duplicates
  • alignment-filtering - Filter low-quality reads
  • chip-seq/chipseq-qc - ChIP-specific metrics

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