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bio-clinical-databases-myvariant-queries

Maintainer FreedomIntelligence · Last updated April 1, 2026

Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.

OpenClawNanoClawAnalysisReproductionbio-clinical-databases-myvariant-queries🧬 bioinformatics (gptomics bio-* suite)bioinformatics — clinical databases & variant analysisquery

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-myvariant-queries

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • Python: myvariant.MyVariantInfo().getvariants(ids, fields='clinvar,gnomad,dbnsfp').
  • Annotate my variants from multiple databases at once" → Query the myvariant.info aggregation API to retrieve ClinVar, gnomAD, dbSNP, COSMIC, and other annotations in a single request per variant. Python: myvariant.MyVariantInfo().getvariants(ids, fields='clinvar,gnomad,dbnsfp').
  • result = mv.getvariant('chr7:g.140453136A>T').

Source Doc

Excerpt From SKILL.md

Query Single Variant

Goal: Retrieve aggregated annotations for a single variant from multiple databases in one request.

Approach: Query myvariant.info by HGVS notation or rsID, which returns ClinVar, gnomAD, dbSNP, COSMIC, and CADD data.


## Query by rsID

result = mv.getvariant('rs121913527')

## Query by gene and protein change

result = mv.getvariant('BRAF:p.V600E')

Use cases

  • Use when annotating variants with clinical and population data from multiple sources simultaneously.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

  • clinvar-lookup - Detailed ClinVar queries
  • gnomad-frequencies - gnomAD-specific frequency queries
  • dbsnp-queries - dbSNP rsID lookups

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