AR
Data & Repro
armored-cart-design-agent
Design armored CAR-T cells with cytokine payloads and resistance mechanisms.
FreedomIntelligence/OpenClaw-Medical-SkillsView
Data & Repro
BI
bio-fragment-analysis
Maintainer FreedomIntelligence · Last updated April 1, 2026
Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-fragment-analysis
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Python: FinaleToolkit or Griffin for fragment feature extraction.
- Python: pysam for custom fragmentomics analysis.
- Analyze cfDNA fragment patterns for cancer detection" → Extract fragmentomics features (size distributions, nucleosome positioning, DELFI profiles) from cfDNA for tumor detection and tissue-of-origin analysis. Python: FinaleToolkit or Griffin for fragment feature extraction Python: pysam for custom fragmentomics analysis.
- Analyze cfDNA fragmentomics for cancer detection and characterization.
Source Doc
Excerpt From SKILL.md
Genome-Wide Fragmentation Profile
Goal: Generate a genome-wide map of short-to-long fragment ratios across fixed-size bins, replicating the DELFI approach for cancer detection from cfDNA fragmentomics.
Approach: Iterate over proper-pair fragments in each genomic bin, classify each as short (100-150 bp) or long (151-220 bp), and compute the short/long ratio per bin as the fragmentation feature vector.
Use cases
- Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Tool Selection
Griffin
Nucleosome profiling
Upstream Related Skills
- cfdna-preprocessing - Preprocess before fragment analysis
- tumor-fraction-estimation - Complement with CNV-based estimation
- methylation-based-detection - Alternative detection approach
Related skills
Related skills
AR
Data & Repro
arxiv-search
Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic search.
FreedomIntelligence/OpenClaw-Medical-SkillsView
AU
Data & Repro
autonomous-oncology-agent
Autonomous oncology research agent: literature mining, trial matching, biomarker analysis, and treatment hypothesis generation.
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-cfdna-preprocessing
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate remo…
FreedomIntelligence/OpenClaw-Medical-SkillsView