Data & ReproBioinformatics & GenomicsFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

bio-hi-c-analysis-hic-data-io

Maintainer FreedomIntelligence · Last updated April 1, 2026

Load, convert, and manipulate Hi-C contact matrices using cooler format. Read.cool/.mcool files, convert from.hic format, access matrix data, and export to different formats. Use when loading or converting Hi-C contact matrices.

OpenClawNanoClawAnalysisReproductionbio-hi-c-analysis-hic-data-io🧬 bioinformatics (gptomics bio-* suite)bioinformatics — epigenomics & chromatinload

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-hi-c-analysis-hic-data-io

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

Python: cooler.Cooler('file.mcool::resolutions/10000').
CLI: cooler load, hic2cool convert.
Load my Hi-C contact matrix" → Read.cool/.mcool/.hic files into Python, access contact pixels, convert between formats, and export subsets. Python: cooler.Cooler('file.mcool::resolutions/10000') CLI: cooler load, hic2cool convert.
Load and manipulate Hi-C contact matrices in cooler format.
clr = cooler.Cooler('matrix.cool').

Source Doc

Excerpt From SKILL.md

Basic info

print(f'Chromosomes: {clr.chromnames}') print(f'Bin size: {clr.binsize}') print(f'Number of bins: {clr.info["nbins"]}') print(f'Sum of counts: {clr.info["sum"]}')


## List available resolutions

resolutions = cooler.fileops.list_coolers('matrix.mcool')
print(f'Available resolutions: {resolutions}')

## Load specific resolution

clr = cooler.Cooler('matrix.mcool::resolutions/10000')
print(f'Loaded at {clr.binsize}bp resolution')