AL
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bio-immunoinformatics-mhc-binding-prediction
Maintainer FreedomIntelligence · Last updated April 1, 2026
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-immunoinformatics-mhc-binding-prediction
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Python: mhcflurry.Class1PresentationPredictor().predict() for MHC-I.
- CLI: netMHCpan for alternative MHC-I/II predictions.
- Predict which peptides bind to MHC" → Predict peptide-MHC class I and II binding affinity using neural network models to identify potential T-cell epitopes from protein sequences. Python: mhcflurry.Class1PresentationPredictor().predict() for MHC-I CLI: netMHCpan for alternative MHC-I/II predictions.
- mhcflurry-downloads fetch.
Source Doc
Excerpt From SKILL.md
MHCflurry Setup
Goal: Install MHCflurry and download pre-trained prediction models.
Approach: Install via pip and fetch model weights for class I pan-allele or specific allele predictions.
## Download models for specific alleles
mhcflurry-downloads fetch models_class1_pan
MHCflurry Python API
Goal: Predict peptide-MHC binding affinity and presentation scores for a set of peptides.
Approach: Load the Class1PresentationPredictor and call predict() with peptide-allele pairs to obtain IC50, percentile rank, and presentation scores.
from mhcflurry import Class1PresentationPredictor
Use cases
- Use when predicting MHC binding for vaccine design or neoantigen identification.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- immunoinformatics/neoantigen-prediction - Tumor neoantigen discovery
- immunoinformatics/epitope-prediction - B-cell epitope prediction
- clinical-databases/hla-typing - Determine patient HLA type
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