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bio-population-genetics-selection-statistics
Maintainer FreedomIntelligence · Last updated April 1, 2026
Detect natural selection signatures: iHS, XP-EHH, Tajima's D.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-population-genetics-selection-statistics
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Detect natural selection signatures using diversity statistics and extended haplotype homozygosity.
- vcftools --vcf data.vcf --weir-fst-pop pop1.txt --weir-fst-pop pop2.txt --out fst_result.
Source Doc
Excerpt From SKILL.md
With window
vcftools --vcf data.vcf --weir-fst-pop pop1.txt --weir-fst-pop pop2.txt
--fst-window-size 100000 --fst-window-step 50000 --out fst_windowed
## Interpretation
| D Value | Interpretation |
|---------|---------------|
| D < -2 | Recent selective sweep or population expansion |
| D ≈ 0 | Neutral evolution |
| D > 2 | Balancing selection or population bottleneck |
## vcftools
```bash
vcftools --vcf data.vcf --TajimaD 100000 --out tajima
Use cases
- Use bio-population-genetics-selection-statistics for genomics and bioinformatics workflows.
- Apply bio-population-genetics-selection-statistics to sequencing, variant, or omics analysis tasks.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- scikit-allel-analysis - Data loading and basic statistics
- population-structure - Population assignment for Fst
- linkage-disequilibrium - EHH depends on LD patterns
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