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bio-systems-biology-gene-essentiality

Maintainer FreedomIntelligence · Last updated April 1, 2026

Predict essential genes by single gene knockouts in metabolic models.

OpenClawNanoClawAnalysisReproductionbio-systems-biology-gene-essentiality🧠 bioos extended suitebioos extended bioinformatics suitepredict

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-systems-biology-gene-essentiality

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

deletion_results = single_gene_deletion(model).
essential = deletion_results[deletion_results['growth'] < 0.01] print(f'Essential genes: {len(essential)}').

Source Doc

Excerpt From SKILL.md

Single Gene Knockouts

import cobra
from cobra.flux_analysis import single_gene_deletion

model = cobra.io.load_model('textbook')

## Synthetic Lethality

```python
from cobra.flux_analysis import double_gene_deletion

## Subset to genes of interest

genes_of_interest = [g.id for g in model.genes[:50]]

Use cases

Use bio-systems-biology-gene-essentiality for genomics and bioinformatics workflows.
Apply bio-systems-biology-gene-essentiality to sequencing, variant, or omics analysis tasks.