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FreedomIntelligence/OpenClaw-Medical-SkillsView
Data & Repro
BI
bio-workflows-merip-pipeline
Maintainer FreedomIntelligence · Last updated April 1, 2026
MeRIP-seq: m6A peak calling → differential → motif analysis.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-workflows-merip-pipeline
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Source Doc
Excerpt From SKILL.md
QC Checkpoints
| Checkpoint | Expected | Action if Failed |
|---|---|---|
| IP/Input alignment rate | >80% | Check adapter contamination |
| IP/Input correlation | r < 0.8 | Verify IP enrichment |
| Peak count | 10,000-50,000 | Adjust -q threshold |
| DRACH motif in peaks | >50% | Check peak calling parameters |
| Stop codon enrichment | Clear peak | Confirm m6A signal |
Output Files
| File | Description |
|---|---|
m6a_peaks.bed | Called m6A peak locations |
m6a_peaks_annotated.txt | Peaks with gene annotations |
diff_m6a.csv | Differential methylation results |
metagene.pdf | Peak distribution across transcripts |
motif_output/ | Enriched motifs (expect DRACH) |
Use cases
- Use bio-workflows-merip-pipeline for genomics and bioinformatics workflows.
- Apply bio-workflows-merip-pipeline to sequencing, variant, or omics analysis tasks.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- epitranscriptomics/m6a-peak-calling - Detailed peak calling options
- epitranscriptomics/m6a-differential - Differential analysis methods
- epitranscriptomics/modification-visualization - Visualization techniques
- chip-seq/peak-calling - Similar IP-based peak calling concepts
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