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cellfree-rna-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Cell-free RNA analysis: plasma cfRNA profiling for liquid biopsy diagnostics.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/cellfree-rna-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The Cell-Free RNA Analysis Agent provides comprehensive analysis of circulating cell-free RNA (cfRNA) from plasma and other biofluids for cancer detection, tissue-of-origin identification, and non-invasive transcriptomic profiling.
- When analyzing plasma cfRNA for cancer detection and monitoring.
- To identify tissue-of-origin from circulating transcripts.
- For non-invasive transcriptomic profiling of tumors.
- When integrating cfRNA with cfDNA for comprehensive liquid biopsy.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
cfRNA Profiling: Quantify mRNA, lncRNA, and small RNA from plasma.
-
Tissue Deconvolution: Identify tissue sources contributing to cfRNA pool.
-
Cancer Detection: ML models detecting cancer from cfRNA profiles.
-
Tumor Transcriptomics: Infer tumor gene expression non-invasively.
-
Integration with cfDNA: Combine RNA and DNA liquid biopsy analytes.
-
Biomarker Discovery: Identify diagnostic and prognostic RNA markers.
cfRNA Biology
Sources:
- Cell death (apoptosis, necrosis)
- Active secretion (EVs, RNA-binding proteins)
- Cell surface-associated RNA
Protection Mechanisms:
- Extracellular vesicles
- Protein complexes (AGO2, NPM1)
- Lipoproteins
Half-life: Minutes to hours (shorter than cfDNA)
Workflow
-
Input: Plasma cfRNA sequencing data (total RNA, small RNA, or targeted).
-
Quality Control: Assess library complexity, mapping rates, contamination.
-
Quantification: Normalize and quantify transcripts.
-
Deconvolution: Estimate tissue contributions.
-
Classification: Apply cancer detection models.
-
Integration: Combine with cfDNA if available.
-
Output: Tissue composition, cancer score, biomarker profiles.
Use cases
- Use cellfree-rna-agent for medicinal chemistry and drug-discovery work.
- Apply cellfree-rna-agent to compound, target, or screening workflows.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- Liquid_Biopsy_Analytics_Agent - For comprehensive liquid biopsy
- Exosome_EV_Analysis_Agent - For EV-derived RNA
- ctDNA_Analysis - For DNA-based markers
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