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chip-clonal-hematopoiesis-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Clonal hematopoiesis of indeterminate potential (CHIP) variant detection and risk assessment.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/chip-clonal-hematopoiesis-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The CHIP Clonal Hematopoiesis Agent provides comprehensive detection and risk stratification of clonal hematopoiesis of indeterminate potential (CHIP). It identifies clonal mutations in blood cells, assesses risk of progression to myeloid malignancy, and predicts cardiovascular disease risk, integrating with the CHIC machine learning framework for CBC-based screening.
- When detecting CHIP mutations from blood sequencing data.
- For stratifying risk of progression to MDS/AML.
- To assess CHIP-associated cardiovascular disease risk.
- When filtering CHIP variants from tumor liquid biopsy.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
CHIP Detection: Identify clonal mutations with VAF >2%.
-
Risk Stratification: Predict myeloid malignancy progression risk.
-
CVD Risk Assessment: Estimate cardiovascular disease risk.
-
CCUS Classification: Distinguish CHIP from CCUS/MDS.
-
Clone Size Tracking: Monitor clonal evolution over time.
-
ctDNA Filtering: Remove CHIP from tumor ctDNA analysis.
CHIP-Associated Genes
| Gene | Frequency | Malignancy Risk | CVD Risk |
|---|---|---|---|
| DNMT3A | 50% | Moderate | Elevated |
| TET2 | 20% | Moderate | Elevated (inflammatory) |
| ASXL1 | 10% | High | Moderate |
| JAK2 | 5% | High (MPN) | Elevated (thrombosis) |
| TP53 | 5% | Very High | Low |
| SF3B1 | 3% | Moderate-High | Low |
| SRSF2 | 3% | High | Low |
| PPM1D | 2% | Moderate | Therapy-related |
| CBL | 2% | High | Moderate |
| IDH1/2 | 2% | Moderate-High | Low |
Risk Categories
| Category | Criteria | Annual AML Risk |
|---|---|---|
| Low-Risk CHIP | DNMT3A/TET2, VAF <10% | <0.5% |
| Intermediate CHIP | DNMT3A/TET2, VAF >10% | 0.5-1% |
| High-Risk CHIP | ASXL1, TP53, splicing | 1-3% |
| CCUS | CHIP + cytopenia | 3-10% |
| Pre-MDS | High-risk mutations + dysplasia | >10% |
Use cases
- When detecting CHIP mutations from blood sequencing data.
- For stratifying risk of progression to MDS/AML.
- To assess CHIP-associated cardiovascular disease risk.
- When filtering CHIP variants from tumor liquid biopsy.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- MPN_Progression_Monitor_Agent - MPN monitoring
- CHIC_ML_Framework_Agent - CBC-based screening
- MDS_Classification_Agent - MDS diagnosis
- Bone_Marrow_AI_Agent - Morphology analysis
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