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chromosomal-instability-agent

Maintainer FreedomIntelligence · Last updated April 1, 2026

Quantify chromosomal instability (CIN) from copy number and SV data.

OpenClawNanoClawAnalysisReproductionchromosomal-instability-agent🧠 bioos extended suiteoncology & precision medicine agentsquantify

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/chromosomal-instability-agent

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • The Chromosomal Instability Agent analyzes CIN signatures to predict cancer prognosis, immunotherapy response, and therapeutic vulnerabilities. It integrates copy number alterations, aneuploidy scores, and CIN-related gene expression for comprehensive genomic instability assessment.
  • When assessing tumor aneuploidy and chromosomal instability levels.
  • To predict prognosis based on CIN signatures.
  • For identifying tumors vulnerable to CIN-targeted therapies (PARP, ATR, WEE1).
  • When analyzing immune evasion mechanisms related to CIN.

Source Doc

Excerpt From SKILL.md

Core Capabilities

  1. CIN Scoring: Calculate comprehensive CIN scores from copy number data.

  2. Aneuploidy Quantification: Measure arm-level and focal copy number alterations.

  3. CIN Gene Expression: Analyze CIN70 and other transcriptional signatures.

  4. Immune Correlation: Assess CIN-immune microenvironment relationships.

  5. Therapeutic Vulnerability: Identify CIN-targeted treatment options.

  6. Prognostic Modeling: Predict outcomes based on CIN signatures.

CIN Metrics

MetricCalculationInterpretation
Aneuploidy scoreArm-level alterationsChromosome-level CIN
SCNA burdenTotal CNV alterationsOverall instability
Weighted GIIFraction altered genomeFocal vs broad changes
CIN7070-gene signatureTranscriptional CIN
WGIIWeighted genome instabilityComprehensive score

CIN70 Signature Genes

Core genes reflecting CIN phenotype:

  • Mitotic checkpoint: BUB1, BUBR1, MAD2L1
  • Kinetochore: CENPA, CENPF, NDC80
  • DNA replication: MCM2-7, ORC1
  • Cell cycle: CCNB1, CCNB2, CDK1, PLK1
  • Chromosome segregation: AURKB, KIF2C, KIF11

Use cases

  • When assessing tumor aneuploidy and chromosomal instability levels.
  • To predict prognosis based on CIN signatures.
  • For identifying tumors vulnerable to CIN-targeted therapies (PARP, ATR, WEE1).

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

  • HRD_Analysis_Agent - For HR-specific instability
  • Pan_Cancer_MultiOmics_Agent - For pan-cancer context
  • Tumor_Clonal_Evolution_Agent - For evolutionary dynamics

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