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clinical-interpretation
Maintainer FreedomIntelligence · Last updated April 1, 2026
clinical-interpretation.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/clinical-interpretation
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Prioritize and interpret variants for clinical significance using databases and ACMG/AMP guidelines.
Source Doc
Excerpt From SKILL.md
Exclude benign
bcftools view -e 'INFO/CLNSIG~"Benign" || INFO/CLNSIG~"Likely_benign"'
with_clinvar.vcf.gz -Oz -o not_benign.vcf.gz
## ClinVar Significance Levels
| CLNSIG | Meaning | Action |
|--------|---------|--------|
| Pathogenic | Disease-causing | Report |
| Likely_pathogenic | Probably disease-causing | Report with caveat |
| Uncertain_significance | VUS | May report, needs follow-up |
| Likely_benign | Probably not disease-causing | Usually exclude |
| Benign | Not disease-causing | Exclude |
| Conflicting | Multiple interpretations | Manual review |
## ClinVar Review Status
| CLNREVSTAT | Stars | Meaning |
|------------|-------|---------|
| practice_guideline | 4 | Expert panel reviewed |
| reviewed_by_expert_panel | 3 | ClinGen expert reviewed |
| criteria_provided,_multiple_submitters | 2 | Consistent assertions |
| criteria_provided,_single_submitter | 1 | One submitter with criteria |
| no_assertion_criteria | 0 | No criteria provided |
```bash
Use cases
- Use clinical-interpretation for clinical, translational, or medical research tasks.
- Apply clinical-interpretation when healthcare-specific guidance is required.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- variant-calling/variant-annotation - VEP/SnpEff annotation
- variant-calling/filtering-best-practices - Quality filtering
- database-access/entrez-fetch - Download ClinVar/OMIM data
- pathway-analysis/go-enrichment - Gene set analysis
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