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cnv-caller-agent

Maintainer FreedomIntelligence · Last updated April 1, 2026

Specialized CNV detection agent integrating multiple callers with ensemble scoring.

OpenClawNanoClawAnalysisReproductioncnv-caller-agent🧠 bioos extended suitedrug discovery & designspecialized

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/cnv-caller-agent

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • The CNV Caller Agent provides comprehensive AI-enhanced copy number variation analysis from WGS, WES, and targeted sequencing for cancer genomics and constitutional CNV detection.
  • When calling somatic CNVs from tumor-normal paired sequencing.
  • To detect constitutional CNVs from germline sequencing.
  • For allele-specific copy number analysis.
  • When characterizing focal amplifications and deletions in cancer.

Source Doc

Excerpt From SKILL.md

Core Capabilities

  1. Somatic CNV Calling: Detect tumor-specific copy number alterations.

  2. Germline CNV Detection: Identify constitutional CNVs for rare disease.

  3. Allele-Specific Analysis: Determine allele-specific copy number and LOH.

  4. Purity/Ploidy Estimation: Estimate tumor content and genome doubling.

  5. Focal Event Detection: Identify amplifications and deletions of driver genes.

  6. Segmentation Optimization: AI-enhanced breakpoint detection.

Workflow

  1. Input: BAM files (tumor/normal), or targeted panel data.

  2. Coverage Normalization: GC correction, mappability adjustment.

  3. Segmentation: Identify regions of consistent copy number.

  4. Allele-Specific: Calculate B-allele frequency for heterozygosity.

  5. Purity/Ploidy: Estimate sample parameters.

  6. Calling: Assign integer copy number states.

  7. Output: Segmented CNV calls, purity/ploidy, driver events.

Example Usage

User: "Call somatic copy number alterations from this tumor-normal WES pair."

Agent Action:

Use cases

  • When calling somatic CNVs from tumor-normal paired sequencing.
  • To detect constitutional CNVs from germline sequencing.
  • For allele-specific copy number analysis.
  • When characteri.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

  • Variant_Interpretation - For CNV annotation
  • HRD_Analysis_Agent - For HRD scoring from CNV
  • Pan_Cancer_MultiOmics_Agent - For pan-cancer CNV context

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