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CR
crispr-offtarget-predictor
Maintainer FreedomIntelligence · Last updated April 1, 2026
Predict CRISPR Cas9/Cas12 off-target sites genome-wide with CRISPOR/Cas-OFFinder.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/crispr-offtarget-predictor
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- This skill identifies potential off-target binding sites for a specific sgRNA sequence. It helps researchers assess the specificity of their CRISPR design.
- Designing new CRISPR experiments.
- Validating sgRNA specificity before synthesis.
- Analyzing potential safety risks in gene editing protocols.
- Designing new CRISPR experiments. Validating sgRNA specificity before synthesis. * Analyzing potential safety risks in gene editing protocols.
Source Doc
Excerpt From SKILL.md
Core Capabilities
- Mismatch Scoring: Calculates mismatch penalties for potential sites.
- PAM Validation: Filters targets based on PAM (Protospacer Adjacent Motif) compatibility.
- Risk Assessment: Categorizes off-targets as Low, Medium, or High risk.
Workflow
- Input: sgRNA sequence (20nt) and PAM (e.g., NGG).
- Analysis: Scans a reference library (mocked for this version) for similar sequences.
- Output: List of potential off-targets with locations and risk scores.
Example Usage
User: "Check sgRNA 'GAGTCCGAGCAGAAGAAGAA' for off-targets."
Agent Action:
Use cases
- Designing new CRISPR experiments.
- Validating sgRNA specificity before synthesis.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
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