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ctdna-dynamics-mrd-agent

Maintainer FreedomIntelligence · Last updated April 1, 2026

Track ctDNA dynamics for minimal residual disease detection and treatment monitoring.

OpenClawNanoClawAnalysisReproductionctdna-dynamics-mrd-agent🧠 bioos extended suiteoncology & precision medicine agentstrack

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/ctdna-dynamics-mrd-agent

Skill Snapshot

2 min

The ctDNA Dynamics MRD Agent provides comprehensive analysis of circulating tumor DNA dynamics for molecular residual disease (MRD) detection, treatment response monitoring, and early relapse prediction. It integrates tumor-informed and tumor-naive approaches with temporal modeling for longitudinal ctDNA analysis.
When monitoring minimal/molecular residual disease post-treatment.
For tracking treatment response through ctDNA kinetics.
To predict relapse before clinical/radiological detection.
When assessing tumor burden dynamics during therapy.

Source Doc

MRD Detection: Ultra-sensitive detection of residual disease (LOD 0.001% VAF).
Kinetic Modeling: Model ctDNA clearance and doubling time.
Response Prediction: Predict treatment response from early ctDNA dynamics.
Relapse Prediction: Identify molecular relapse months before imaging.
Resistance Monitoring: Track emergence of resistance mutations.
Multi-Timepoint Integration: Analyze longitudinal ctDNA trajectories.

Approach	Method	LOD	Best Use Case
Tumor-Informed	Track known mutations	0.001%	Post-surgical MRD
Tumor-Naive	Panel-based detection	0.1%	Screening, unknown primary
WGS-Based	Fragmentomics + mutations	0.01%	Comprehensive profiling
Methylation	cfDNA methylation	0.1%	Tissue of origin, early detection