Data & ReproProtein Structure & DesignK-Dense-AI/claude-scientific-skillsData & Reproduction

esm

Maintainer K-Dense Inc. · Last updated April 1, 2026

ESM provides state-of-the-art protein language models for understanding, generating, and designing proteins. This skill enables working with two model families: ESM3 for generative protein design across sequence, structure, and function, and ESM C for efficient protein representation learning and embeddings.

Claude CodeOpenClawNanoClawAnalysisReproductionesmbioinformaticspackagebioinformatics & genomics

Original source

K-Dense-AI/claude-scientific-skills

https://github.com/K-Dense-AI/claude-scientific-skills/tree/main/scientific-skills/esm

Maintainer: K-Dense Inc.
License: MIT license
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

ESM provides state-of-the-art protein language models for understanding, generating, and designing proteins. This skill enables working with two model families: ESM3 for generative protein design across sequence, structure, and function, and ESM C for efficient protein representation learning and embeddings.
model: ESM3InferenceClient = ESM3.from_pretrained("esm3-sm-open-v1").to("cuda").

Source Doc

Excerpt From SKILL.md

1. Protein Sequence Generation with ESM3

Generate novel protein sequences with desired properties using multimodal generative modeling.

When to use:

Designing proteins with specific functional properties
Completing partial protein sequences
Generating variants of existing proteins
Creating proteins with desired structural characteristics

Basic usage:

from esm.models.esm3 import ESM3
from esm.sdk.api import ESM3InferenceClient, ESMProtein, GenerationConfig

## Create protein prompt

protein = ESMProtein(sequence="MPRT___KEND")  # '_' represents masked positions

## Generate completion

protein = model.generate(protein, GenerationConfig(track="sequence", num_steps=8))
print(protein.sequence)
python
from esm.sdk.forge import ESM3ForgeInferenceClient
from esm.sdk.api import ESMProtein, GenerationConfig