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gene-panel-design-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Design targeted gene panels for clinical or research sequencing applications.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/gene-panel-design-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The Gene Panel Design Agent provides AI-driven design of targeted sequencing panels for clinical diagnostics, cancer profiling, pharmacogenomics, and research applications.
- When designing custom gene panels for clinical or research use.
- To optimize panel content for specific disease areas.
- For balancing panel size with diagnostic yield.
- When designing probes for hybrid capture or amplicon approaches.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Gene Selection: Evidence-based gene prioritization for disease areas.
-
Target Region Definition: Specify exons, introns, UTRs, promoters to include.
-
Probe Design: In silico probe/primer design for capture or amplicon.
-
Coverage Prediction: Estimate uniformity and dropout risk.
-
Validation Planning: Design positive controls and performance metrics.
-
Cost Optimization: Balance panel size with clinical utility.
Workflow
-
Input: Disease focus, required genes, platform choice, size constraints.
-
Gene Prioritization: Rank genes by clinical evidence level.
-
Region Definition: Define target coordinates.
-
Probe Design: Generate capture probes or primers.
-
Coverage Simulation: Predict sequencing performance.
-
Optimization: Iterate design for uniformity.
-
Output: Panel BED file, probe sequences, validation plan.
Example Usage
User: "Design a comprehensive solid tumor panel covering actionable mutations and resistance markers."
Agent Action:
Use cases
- When designing custom gene panels for clinical or research use.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- CRISPR_Design_Agent - For guide design
- Variant_Interpretation - For variant selection
- Tumor_Mutational_Burden_Agent - For TMB panel requirements
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