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genome-compare
Maintainer FreedomIntelligence · Last updated April 1, 2026
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/genome-compare
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.
- python skills/genome-compare/genome_compare.py --demo --output results/.
Source Doc
Excerpt From SKILL.md
Why This Exists
- Without it: Comparing two genomes requires PLINK, custom scripts, and ancestry reference panels — hours of bioinformatics setup
- With it: Upload a 23andMe file and instantly see IBS similarity to George Church, per-chromosome breakdown, and ancestry composition
- Why ClawBio: Uses a bundled PGP-1 reference genome (CC0 public domain) and an EM admixture algorithm calibrated to continental ancestry-informative markers
Core Capabilities
- Identity By State (IBS): Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report SNP overlap, identity, and relationship context.
- Ancestry Composition: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm.
- Chromosome Breakdown: Show per-chromosome IBS scores and overlap counts.
Input Formats
| Format | Extension | Required Fields | Example |
|---|---|---|---|
| 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | data/manuel_corpas_23andme.txt.gz |
Use cases
- Use genome-compare for medicinal chemistry and drug-discovery work.
- Apply genome-compare to compound, target, or screening workflows.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
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