AD
Data & Repro
Adaptyv
Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or…
K-Dense-AI/claude-scientific-skillsView
Data & Repro
GL
glycoengineering
Maintainer Kuan-lin Huang · Last updated April 1, 2026
Glycosylation is the most common and complex post-translational modification (PTM) of proteins, affecting over 50% of all human proteins. Glycans regulate protein folding, stability, immune recognition, receptor interactions, and pharmacokinetics of therapeutic proteins. Glycoengineering involves rational modification of glycosylation patterns for improved therapeutic efficacy, stability, or immune evasion. **Two ma….
Original source
K-Dense-AI/claude-scientific-skills
https://github.com/K-Dense-AI/claude-scientific-skills/tree/main/scientific-skills/glycoengineering
- Maintainer
- Kuan-lin Huang
- License
- Unknown
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- N-glycosylation: Attached to asparagine (N) in the sequon N-X-[S/T] where X ≠ Proline; occurs in the ER/Golgi.
- O-glycosylation: Attached to serine (S) or threonine (T); no strict consensus motif; primarily GalNAc initiation.
- Glycosylation is the most common and complex post-translational modification (PTM) of proteins, affecting over 50% of all human proteins. Glycans regulate protein folding, stability, immune recognition, receptor interactions, and pharmacokinetics of therapeutic proteins. Glycoengineering involves rational modification of glycosylation patterns for improved therapeutic efficacy, stability, or immune evasion.
- Two major glycosylation types: N-glycosylation: Attached to asparagine (N) in the sequon N-X-[S/T] where X ≠ Proline; occurs in the ER/Golgi O-glycosylation: Attached to serine (S) or threonine (T); no strict consensus motif; primarily GalNAc initiation.
- fc_sequence = "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK" print(summarize_glycosylation_sites(fc_sequence, "IgG1 Fc")).
Source Doc
Excerpt From SKILL.md
When to Use This Skill
Use this skill when:
- Antibody engineering: Optimize Fc glycosylation for enhanced ADCC, CDC, or reduced immunogenicity
- Therapeutic protein design: Identify glycosylation sites that affect half-life, stability, or immunogenicity
- Vaccine antigen design: Engineer glycan shields to focus immune responses on conserved epitopes
- Biosimilar characterization: Compare glycan patterns between reference and biosimilar
- Drug target analysis: Does glycosylation affect target engagement for a receptor?
- Protein stability: N-glycans often stabilize proteins; identify sites for stabilizing mutations
Use cases
- **Antibody engineering**: Optimi.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
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