AA
Data & Repro
aav-vector-design-agent
AAV vector design: capsid selection, promoter optimization, payload capacity.
FreedomIntelligence/OpenClaw-Medical-SkillsView
Data & Repro
GW
gwas-prs
Maintainer FreedomIntelligence · Last updated April 1, 2026
Calculate polygenic risk scores from DTC genetic data using the PGS Catalog.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/gwas-prs
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- You are GWAS-PRS, a specialised ClawBio agent for polygenic risk score calculation. Your role is to compute polygenic risk scores (PRS) from direct-to-consumer (DTC) genetic data using published scoring files from the PGS Catalog, and to contextualise those scores against reference population distributions.
- GET https://www.pgscatalog.org/rest/score/search?trait_id=EFO_0001360.
Source Doc
Excerpt From SKILL.md
Core Capabilities
- Search PGS Catalog: Query the PGS Catalog REST API for published polygenic scores across 3,000+ scores and 667+ traits. Filter by trait, publication, ancestry, and number of variants.
- Calculate PRS: Parse 23andMe or AncestryDNA genotype files, match variants to a PGS scoring file, compute dosage-weighted risk scores using the standard additive model: PRS = sum(dosage_i * effect_weight_i).
- Estimate Population Percentiles: Compare individual PRS against reference population distributions (mean/SD) to estimate percentile rank and assign risk categories (low / average / elevated / high).
Input Formats
- 23andMe (.txt): Tab-separated file with columns
rsid,chromosome,position,genotype. Comment lines begin with#. - AncestryDNA (.txt/.csv): Tab-separated or CSV with columns
rsid,chromosome,position,allele1,allele2. Comment lines begin with#.
Both formats report genotypes on the forward strand (GRCh37). The tool handles both combined genotype (e.g., AG) and split allele formats.
Use cases
- Use gwas-prs for medicinal chemistry and drug-discovery work.
- Apply gwas-prs to compound, target, or screening workflows.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Related skills
Related skills
AG
Data & Repro
agentd-drug-discovery
AgentD autonomous drug discovery: target identification, hit finding, ADMET optimization.
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-clinical-databases-hla-typing
Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for tr…
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-clinical-databases-pharmacogenomics
Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response fr…
FreedomIntelligence/OpenClaw-Medical-SkillsView