Data & ReproClinical MedicineFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

hemoglobinopathy-analysis-agent

Maintainer FreedomIntelligence · Last updated April 1, 2026

Hemoglobin variant analysis, sickle cell, and thalassemia genotype-phenotype assessment.

OpenClawNanoClawAnalysisReproductionhemoglobinopathy-analysis-agent🧠 bioos extended suitehematology & blood disordershemoglobin

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/hemoglobinopathy-analysis-agent

Skill Snapshot

2 min

The Hemoglobinopathy Analysis Agent provides comprehensive AI-driven analysis of hemoglobin disorders. It integrates HPLC chromatograms, electrophoresis patterns, CBC parameters, and molecular genetics for diagnosis and management of sickle cell disease, thalassemias, and variant hemoglobins.
When interpreting HPLC hemoglobin chromatograms for variant identification.
To diagnose and classify thalassemia syndromes (α, β, δβ).
For comprehensive sickle cell disease phenotype assessment.
When correlating genotype with clinical phenotype severity.

Source Doc

HPLC Interpretation: AI pattern recognition for hemoglobin variant identification from HPLC chromatograms.
Thalassemia Classification: Distinguish α-thalassemia (silent carrier to Hb Bart's) and β-thalassemia (minor to major).
Sickle Cell Phenotyping: Integrate HbS%, HbF%, α-globin status for phenotype prediction.
Variant Identification: Database matching for >1,500 known hemoglobin variants.
Molecular Correlation: Link genetic variants (HBB, HBA1/2) to protein phenotypes.
Management Guidance: Treatment recommendations based on disease severity.

Condition	HbA	HbA2	HbF	Variants	RBC Indices
Normal adult	96-98%	2-3%	<1%	-	Normal
β-thal trait	92-95%	3.5-7%	1-3%	-	Microcytic
β-thal major	0-10%	Variable	90-95%	-	Severe anemia
α-thal trait	97-98%	2-3%	<1%	-	Microcytic
HbH disease	70-90%	1-2%	<1%	HbH 5-30%	Moderate anemia
Sickle trait	55-60%	2-3%	<1%	HbS 38-45%	Normal
Sickle cell	0%	2-3%	2-20%	HbS 80-95%	Sickle cells

Input: HPLC chromatogram, CBC with indices, peripheral smear findings, molecular data (if available).
Pattern Recognition: AI analysis of HPLC retention times and peak areas.
Variant Matching: Compare against hemoglobin variant database.
RBC Correlation: Integrate MCV, MCH, RDW, reticulocyte count.
Phenotype Classification: Assign clinical phenotype category.
Management: Generate treatment and monitoring recommendations.
Output: Diagnosis, variant identification, clinical classification, management plan.