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hrd-analysis-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Homologous recombination deficiency (HRD) analysis for PARP inhibitor response prediction.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/hrd-analysis-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The HRD Analysis Agent provides comprehensive analysis of homologous recombination deficiency for predicting response to PARP inhibitors and platinum chemotherapy. It integrates genomic scarring signatures (LOH, TAI, LST), BRCA1/2 status, and HRD gene pathway analysis.
- When determining HRD status for PARP inhibitor eligibility.
- To calculate genomic instability scores (GIS) from tumor sequencing.
- For analyzing BRCA1/2 and HRD gene mutations.
- When predicting response to PARP inhibitors or platinum chemotherapy.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Genomic Scar Scoring: Calculate LOH, TAI, and LST scores from copy number data.
-
BRCA Pathway Analysis: Assess mutations in BRCA1, BRCA2, and 13 other HRD genes.
-
HRD Classification: Determine HRD-positive vs. HRD-negative status.
-
PARP Inhibitor Prediction: Predict response to olaparib, niraparib, rucaparib, talazoparib.
-
Platinum Sensitivity: Predict platinum chemotherapy sensitivity.
-
Reversion Detection: Identify BRCA reversion mutations restoring HR function.
HRD Scoring Components
| Score | Definition | Biological Basis |
|---|---|---|
| LOH | Loss of heterozygosity regions >15 Mb | Genomic scarring |
| TAI | Telomeric allelic imbalance | End-to-end fusions |
| LST | Large-scale state transitions | Break-induced repair |
| GIS | Combined LOH + TAI + LST | Overall HRD score |
HRD-Positive Threshold: GIS ≥ 42 (Myriad myChoice) or equivalent
HRD Gene Panel
| Gene | Function | HRD Contribution |
|---|---|---|
| BRCA1 | HR core component | Major |
| BRCA2 | RAD51 loading | Major |
| PALB2 | BRCA2 partner | Moderate-Major |
| RAD51C/D | HR mediators | Moderate |
| ATM | DNA damage sensing | Moderate |
| CHEK2 | Cell cycle checkpoint | Moderate |
| BARD1 | BRCA1 partner | Moderate |
| BRIP1 | Fanconi pathway | Moderate |
| CDK12 | Transcription | Variable |
| RAD51B | HR mediator | Low-Moderate |
Use cases
- When determining HRD status for PARP inhibitor eligibility.
- To calculate genomic instability scores (GIS) from tumor sequencing.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- Variant_Interpretation - For BRCA classification
- Liquid_Biopsy_Analytics_Agent - For ctDNA HRD monitoring
- Pan_Cancer_MultiOmics_Agent - For multi-omic context
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