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mpn-progression-monitor-agent

Maintainer FreedomIntelligence · Last updated April 1, 2026

Myeloproliferative neoplasm progression monitoring from serial molecular data.

OpenClawNanoClawAnalysisReproductionmpn-progression-monitor-agent🧠 bioos extended suitehematology & blood disordersmyeloproliferative

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/mpn-progression-monitor-agent

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • The MPN Progression Monitor Agent provides comprehensive monitoring of myeloproliferative neoplasms (PV, ET, MF) for disease progression, treatment response, and transformation risk. It integrates molecular profiling, clinical parameters, and AI-based risk models to guide management of chronic phase disease and predict blast transformation.
  • When monitoring JAK2/CALR/MPL mutation burden over time.
  • For predicting fibrosis progression in PV/ET.
  • To assess risk of blast transformation.
  • When tracking treatment response to JAK inhibitors.

Source Doc

Excerpt From SKILL.md

Core Capabilities

  1. Mutation Monitoring: Track driver and high-risk mutation VAF.

  2. Progression Prediction: Model fibrosis and transformation risk.

  3. Risk Scoring: Calculate DIPSS, MIPSS70+, MTSS dynamically.

  4. Treatment Response: Assess molecular and clinical response.

  5. Clone Evolution: Track clonal dynamics and new mutations.

  6. Transplant Timing: Optimize allo-HSCT timing decisions.

MPN Classification

MPN TypeDriver MutationsProgression Risk
PVJAK2 V617F (95%), JAK2 exon 12Fibrosis 10-15%, AML 2-5%
ETJAK2 (55%), CALR (25%), MPL (5%)Fibrosis 5-10%, AML 1-2%
Pre-PMFSame as PMFVariable
PMFJAK2 (60%), CALR (25%), MPL (5%)AML 10-20%

High-Risk Mutations

MutationImpactMF Association
ASXL1AdverseStrong
SRSF2AdverseStrong (PMF)
EZH2AdverseModerate
IDH1/2AdverseTransformation
RUNX1Very AdverseTransformation
TP53Very AdverseTransformation
U2AF1AdverseModerate

Use cases

  • When monitoring JAK2/CALR/MPL mutation burden over time.
  • For predicting fibrosis progression in PV/ET.
  • To assess risk of blast transformation.
  • When tracking treatment response to JAK inhibitors.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

  • CHIP_Clonal_Hematopoiesis_Agent - Pre-MPN states
  • MDS_Classification_Agent - Overlap syndromes
  • Bone_Marrow_AI_Agent - Morphology analysis
  • Coagulation_Thrombosis_Agent - Thrombosis risk

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