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mpn-research-assistant
Maintainer FreedomIntelligence · Last updated April 1, 2026
Research assistant for myeloproliferative neoplasms: literature, mutation analysis, treatment.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/mpn-research-assistant
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- mechanism = """ PPM1D inhibition → ↑p53 phosphorylation → ↑p53 stabilization → ↑DNA damage response → ↑apoptosis in mutant clones """.
- ecm_markers = ['COL1A1', 'COL3A1', 'FN1', 'LAMA1', 'LAMB1'].
Source Doc
Excerpt From SKILL.md
WHO 2022 Classification
- Polycythemia Vera (PV): JAK2V617F (95%), JAK2 exon 12 (3%)
- Essential Thrombocythemia (ET): JAK2V617F (55%), CALR (25%), MPL (5%)
- Primary Myelofibrosis (PMF): JAK2V617F (55%), CALR (25%), MPL (8%)
- Pre-PMF: Early fibrotic stage, better prognosis
- Overt PMF: Grade 2-3 fibrosis, splenomegaly
Driver Mutations
| Mutation | Gene Location | Mechanism | VAF Significance |
|---|---|---|---|
| JAK2V617F | 9p24.1 | Constitutive JAK-STAT activation | >50% → poor prognosis |
| CALR (type 1) | 19p13.2 | 52bp deletion, MPL activation | Better prognosis |
| CALR (type 2) | 19p13.2 | 5bp insertion, MPL activation | Intermediate |
| MPL W515L/K | 1p34.2 | TPO-independent signaling | Thrombocytosis |
High Molecular Risk (HMR) Mutations
- ASXL1, EZH2, SRSF2, IDH1/2, U2AF1
- ≥2 HMR mutations = very high risk
Use cases
- Use mpn-research-assistant for clinical, translational, or medical research tasks.
- Apply mpn-research-assistant when healthcare-specific guidance is required.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
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