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multi-ancestry-prs-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Multi-ancestry polygenic risk score computation with ancestry-specific weighting.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/multi-ancestry-prs-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The Multi-Ancestry PRS Agent provides AI-optimized polygenic risk score calculation designed to work across diverse ancestral populations. It addresses the critical limitation of European-biased GWAS by integrating trans-ancestry methods, improving risk prediction for underrepresented populations and enabling equitable precision medicine.
- When calculating PRS for non-European ancestry individuals.
- For developing trans-ancestry risk prediction models.
- To reduce PRS bias across ancestral populations.
- When integrating multi-ancestry GWAS summary statistics.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Multi-Ancestry PRS: Calculate ancestry-aware polygenic scores.
-
Trans-Ancestry Optimization: Optimize weights across populations.
-
Local Ancestry Integration: Account for admixed genomes.
-
Ensemble Methods: Combine multiple PRS approaches.
-
Ancestry Calibration: Population-specific score calibration.
-
Equity Assessment: Evaluate prediction fairness across groups.
Supported Ancestries
| Ancestry | Training Data Availability | PRS Performance |
|---|---|---|
| European (EUR) | Excellent | High |
| East Asian (EAS) | Good | Good |
| South Asian (SAS) | Moderate | Moderate |
| African (AFR) | Limited | Lower |
| Hispanic/Latino (AMR) | Limited | Variable |
| Middle Eastern (MID) | Very Limited | Lower |
Multi-Ancestry Methods
| Method | Approach | Best For |
|---|---|---|
| PRS-CSx | Cross-population shrinkage | Multi-ancestry |
| PRS-Multi | Multi-population training | Large cohorts |
| Ensemble | Combined methods | Best overall |
| Local Ancestry | Ancestry-specific weights | Admixed populations |
| GPSMult | Integrated multi-trait | Correlated traits |
Use cases
- When calculating PRS for non-European ancestry individuals.
- For developing trans-ancestry risk prediction models.
- To reduce PRS bias across ancestral populations.
- When integrating multi-ancestry GWAS summary statistics.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- PRS_Net_Deep_Learning_Agent - Deep learning PRS
- Pharmacogenomics_Agent - Drug-gene interactions
- PopEVE_Variant_Predictor_Agent - Variant interpretation
- DiagAI_Agent - Clinical integration
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