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NK
nk-cell-therapy-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
NK cell therapy design: receptor engineering, expansion protocols, persistence.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/nk-cell-therapy-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The NK Cell Therapy Agent provides AI-driven design and optimization of natural killer cell therapies for cancer treatment. It covers CAR-NK engineering, cytokine-induced memory-like (CIML) NK generation, KIR/HLA matching, and NK cell expansion optimization.
- When designing CAR-NK constructs for tumor targeting.
- To optimize KIR/HLA mismatch for allogeneic NK therapy.
- For generating memory-like NK cells with enhanced persistence.
- When predicting NK cell activation against specific tumor types.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
CAR-NK Design: Design chimeric antigen receptors optimized for NK cell biology (NK-specific signaling domains).
-
KIR/HLA Matching: Predict KIR-HLA interactions for donor selection in allogeneic therapy.
-
Memory-Like NK Generation: Optimize CIML protocol with IL-12/15/18 cytokine preactivation.
-
Expansion Optimization: ML models for feeder-free NK expansion conditions.
-
Tumor Target Prediction: Match NK receptor profiles to tumor ligand expression.
-
Persistence Enhancement: Engineering strategies for improved in vivo survival.
NK Cell Advantages Over T Cells
| Feature | NK Cells | T Cells |
|---|---|---|
| MHC requirement | No | Yes |
| Allogeneic use | Yes (no GVHD) | Limited (GVHD risk) |
| CRS risk | Lower | Higher |
| Off-the-shelf | Yes | Autologous typical |
| Antigen escape | Multiple receptors | Single CAR |
| Persistence | Shorter | Longer |
Workflow
-
Input: Target antigen, tumor type, NK source (PB, UCB, iPSC, cell line).
-
CAR Design: Generate optimized CAR-NK construct sequence.
-
KIR Analysis: Determine KIR genotype and HLA matching for donors.
-
Activation Protocol: Optimize cytokine cocktail for desired phenotype.
-
Expansion: Design feeder-based or feeder-free expansion protocol.
-
Quality Prediction: Predict NK product functionality.
-
Output: CAR sequence, donor recommendations, expansion protocol, QC metrics.
Use cases
- When designing CAR-NK constructs for tumor targeting.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- CART_Design_Optimizer_Agent - For CAR engineering principles
- Epitope_Prediction_Agent - For target selection
- Flow_Cytometry_AI - For NK phenotyping
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