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organoid-drug-response-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
Analyze drug response in patient-derived organoids for personalized therapy prediction.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/organoid-drug-response-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The Organoid Drug Response Agent provides AI-driven analysis of patient-derived organoid (PDO) drug screening data for personalized treatment selection. It correlates organoid drug responses with patient outcomes and molecular profiles to guide precision oncology decisions.
- When interpreting organoid drug screening results for treatment selection.
- To correlate PDO drug sensitivity with molecular features.
- For identifying combination therapies using organoid co-culture systems.
- When predicting patient response from organoid-derived data.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Drug Response Analysis: Process organoid viability data to calculate IC50, AUC, and response metrics.
-
Patient-Organoid Concordance: Assess molecular fidelity between PDO and donor tumor.
-
Biomarker Discovery: Identify molecular features predicting drug sensitivity.
-
Combination Screening: Analyze drug synergy from combination matrices.
-
Clinical Translation: Project organoid findings to patient treatment recommendations.
-
Microenvironment Modeling: Analyze immune co-culture and CAF interactions.
Organoid Advantages
| Feature | Organoids | Cell Lines | PDX |
|---|---|---|---|
| Patient fidelity | High | Low | High |
| Establishment rate | 60-90% | Variable | 30-50% |
| Turnaround | 4-8 weeks | Fast | 3-6 months |
| Throughput | Medium-high | Very high | Low |
| Microenvironment | Partial | None | Mouse |
| Cost | Medium | Low | High |
Workflow
-
Input: Organoid drug screening data, organoid molecular profiles, patient tumor data.
-
QC: Assess organoid viability and growth metrics.
-
Response Calculation: Compute drug sensitivity metrics.
-
Concordance: Compare organoid to donor tumor molecular profiles.
-
Biomarker Analysis: Correlate sensitivity with molecular features.
-
Translation: Generate patient treatment recommendations.
-
Output: Drug rankings, biomarkers, recommended treatments.
Use cases
- When interpreting organoid drug screening results for treatment selection.
- To correlate PDO drug sensitivity with molecular features.
- For identifying combination therapies using organoid co-culture systems.
- When predicting patient response from organoid-derived data.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- PDX_Model_Analysis_Agent - For complementary models
- Drug_Repurposing - For additional drug candidates
- Multi_Omics_Integration - For molecular characterization
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