Data & ReproProtein Structure & DesignFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction
PR

proteinmpnn

Maintainer FreedomIntelligence · Last updated April 1, 2026

Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design. For backbone generation, use rfdiffusion or bindcraft. For ligand-aware design, use ligandmpnn. For….

OpenClawNanoClawAnalysisReproductionproteinmpnn🔬 omics & computational biologyprotein structure & designdesign

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/proteinmpnn

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • -bias_AA_jsonl '{"A": {"A": 1.5, "W": -2.0}}.
  • -omit_AAs "CM" # No cysteine or methionine.

Source Doc

Excerpt From SKILL.md

Prerequisites

RequirementMinimumRecommended
Python3.8+3.10
CUDA11.0+11.7+
GPU VRAM8GB16GB (T4)
RAM8GB16GB

How to run

First time? See Installation Guide to set up Modal and biomodals.

Option 1: Local installation (recommended)

GPU: T4 (16GB) sufficient | Time: ~50-100 sequences/minute

Use cases

  • Use proteinmpnn in research workflows aligned with this subject area.
  • Follow the upstream documentation for the full working procedure.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

Related skills

Related skills

Back to directory
AD
Data & ReproProtein Structure & Design

Adaptyv

Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or…

Claude CodeOpenClawAnalysis
K-Dense-AI/claude-scientific-skillsView
AL
Data & ReproProtein Structure & Design

alphafold

Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) P…

OpenClawNanoClawAnalysis
FreedomIntelligence/OpenClaw-Medical-SkillsView
AL
Data & ReproProtein Structure & Design

AlphaFold DB

AlphaFold DB is a public repository of AI-predicted 3D protein structures for over 200 million proteins, maintained by DeepMind and EMBL-EBI…

Claude CodeOpenClawAnalysis
K-Dense-AI/claude-scientific-skillsView
AN
Data & ReproProtein Structure & Design

antibody-design-agent

Antibody design: epitope mapping, CDR engineering, bispecific construction.

OpenClawNanoClawAnalysis
FreedomIntelligence/OpenClaw-Medical-SkillsView