Data & ReproProtein Structure & DesignFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

solublempnn

Maintainer FreedomIntelligence · Last updated April 1, 2026

Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.

OpenClawNanoClawAnalysisReproductionsolublempnn🔬 omics & computational biologyprotein structure & designsolubility

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/solublempnn

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

python protein_mpnn_run.py \ --pdb_path backbone.pdb \ --out_folder output/ \ --num_seq_per_target 16 \ --sampling_temp "0.1" \ --model_name "v_48_020" # Soluble model.

Source Doc

Excerpt From SKILL.md

How to run

First time? See Installation Guide to set up Modal and biomodals.

Option 1: Modal (recommended)

SolubleMPNN uses the ProteinMPNN Modal wrapper with soluble model:

GPU: T4 (16GB) | Timeout: 600s default

Option 2: Local installation

git clone https://github.com/dauparas/ProteinMPNN.git
cd ProteinMPNN

Use cases

Use solublempnn in research workflows aligned with this subject area.
Follow the upstream documentation for the full working procedure.

Not for

Do not rely on this catalog entry alone for installation or maintenance details.

Related skills

Back to directory

Data & ReproProtein Structure & Design

Adaptyv

Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or…

Claude CodeOpenClawAnalysis

K-Dense-AI/claude-scientific-skillsView

Data & ReproProtein Structure & Design

alphafold

Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) P…

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView

Data & ReproProtein Structure & Design

AlphaFold DB

AlphaFold DB is a public repository of AI-predicted 3D protein structures for over 200 million proteins, maintained by DeepMind and EMBL-EBI…

Claude CodeOpenClawAnalysis

K-Dense-AI/claude-scientific-skillsView

Data & ReproProtein Structure & Design

antibody-design-agent

Antibody design: epitope mapping, CDR engineering, bispecific construction.

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView