AR
Data & Repro
armored-cart-design-agent
Design armored CAR-T cells with cytokine payloads and resistance mechanisms.
FreedomIntelligence/OpenClaw-Medical-SkillsView
Data & Repro
TC
tcr-repertoire-analysis-agent
Maintainer FreedomIntelligence · Last updated April 1, 2026
TCR repertoire analysis: V(D)J usage, clonotype dynamics, antigen specificity.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tcr-repertoire-analysis-agent
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- The TCR Repertoire Analysis Agent provides comprehensive T-cell receptor repertoire analysis for cancer immunology applications. It leverages deep learning and multi-layer machine learning approaches to analyze TCR diversity, predict immunotherapy response, identify tumor-reactive TCRs, and support therapeutic TCR selection for cancer immunotherapy.
- When analyzing TCR repertoire for cancer diagnosis and staging.
- For predicting immunotherapy (anti-PD-1/PD-L1) response from TCR profiles.
- To identify tumor-reactive TCRs for adoptive cell therapy.
- When monitoring treatment response through TCR clonality changes.
Source Doc
Excerpt From SKILL.md
Core Capabilities
-
Repertoire Diversity Analysis: Quantify TCR diversity, clonality, and convergence.
-
Cancer Diagnosis: Distinguish cancer types from TCR signatures.
-
Immunotherapy Response Prediction: Predict checkpoint inhibitor response.
-
Tumor-Reactive TCR Identification: Find neoantigen-specific TCRs.
-
TCR-pMHC Binding Prediction: Predict TCR epitope specificity.
-
Clonal Dynamics Tracking: Monitor TCR clones during treatment.
TCR Repertoire Metrics
| Metric | Definition | Clinical Significance |
|---|---|---|
| Clonality | Gini coefficient of clone sizes | Immune focusing |
| Shannon Entropy | Diversity measure | Immune breadth |
| Richness | Unique clonotypes | Repertoire depth |
| Top Clone % | Largest clone fraction | Dominant response |
| Convergent TCRs | Shared across patients | Public epitope response |
| Tumor-Infiltrating % | TIL-derived TCRs | Tumor reactivity |
Workflow
-
Input: TCR-seq data (bulk or single-cell), clinical metadata.
-
Preprocessing: CDR3 extraction, error correction, clustering.
-
Repertoire Analysis: Calculate diversity, clonality, convergence.
-
ML Classification: Cancer type, stage, response prediction.
-
TCR Prioritization: Rank tumor-reactive TCR candidates.
-
TCR-pMHC Prediction: Predict epitope specificity.
-
Output: Repertoire metrics, predictions, therapeutic candidates.
Use cases
- Use tcr-repertoire-analysis-agent for clinical, translational, or medical research tasks.
- Apply tcr-repertoire-analysis-agent when healthcare-specific guidance is required.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- TCR_pMHC_Prediction_Agent - Detailed TCR-epitope prediction
- Neoantigen_Prediction_Agent - Neoantigen identification
- TME_Immune_Profiling_Agent - Broader immune context
- TCell_Exhaustion_Analysis_Agent - T cell phenotyping
Related skills
Related skills
AR
Data & Repro
arxiv-search
Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic search.
FreedomIntelligence/OpenClaw-Medical-SkillsView
AU
Data & Repro
autonomous-oncology-agent
Autonomous oncology research agent: literature mining, trial matching, biomarker analysis, and treatment hypothesis generation.
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-cfdna-preprocessing
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate remo…
FreedomIntelligence/OpenClaw-Medical-SkillsView