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tooluniverse-cancer-variant-interpretation

Maintainer FreedomIntelligence · Last updated April 1, 2026

Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evide….

OpenClawNanoClawAnalysisReproductiontooluniverse-cancer-variant-interpretation🏥 medical & clinicalmedical toolsprovide

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-cancer-variant-interpretation

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • Comprehensive clinical interpretation of somatic mutations in cancer. Transforms a gene + variant input into an actionable precision oncology report covering clinical evidence, therapeutic options, resistance mechanisms, clinical trials, and prognostic implications.
  • KEY PRINCIPLES: 1. Report-first approach - Create report file FIRST, then populate progressively 2. Evidence-graded - Every recommendation has an evidence tier (T1-T4) 3. Actionable output - Prioritized treatment options, not data dumps 4. Clinical focus - Answer "what should we treat with?" not "what databases exist?" 5. Resistance-aware - Always check for known resistance mechanisms 6. Cancer-type specific - Tailor all recommendations to the patient's cancer type when provided 7. Source-referenced - Every statement must cite the tool/database source 8. English-first queries - Always use English terms in tool calls (gene names, drug names, cancer types), even if the user writes in another language. Respond in the user's language.
  • Date: {date} Cancer Type: {cancer_type or "Not specified"}.

Source Doc

Excerpt From SKILL.md

When to Use

Apply when user asks:

  • "What treatments exist for EGFR L858R in lung cancer?"
  • "Patient has BRAF V600E melanoma - what are the options?"
  • "Is KRAS G12C targetable?"
  • "Patient progressed on osimertinib - what's next?"
  • "What clinical trials are available for PIK3CA E545K?"
  • "Interpret this somatic mutation: TP53 R273H"
  • "Molecular tumor board: EGFR exon 19 deletion, NSCLC"

Input Parsing

Required: Gene symbol + variant notation Optional: Cancer type (improves specificity)

Accepted Input Formats

FormatExampleHow to Parse
Gene + amino acid changeEGFR L858Rgene=EGFR, variant=L858R
Gene + HGVS proteinBRAF p.V600Egene=BRAF, variant=V600E
Gene + exon notationEGFR exon 19 deletiongene=EGFR, variant=exon 19 deletion
Gene + fusionEML4-ALK fusiongene=ALK, variant=EML4-ALK
Gene + amplificationHER2 amplificationgene=ERBB2, variant=amplification
Full query with cancer"EGFR L858R in lung adenocarcinoma"gene=EGFR, variant=L858R, cancer=lung adenocarcinoma

Use cases

  • Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

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