Data & ReproDrug Discovery & CheminformaticsFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

tooluniverse-drug-drug-interaction

Maintainer FreedomIntelligence · Last updated April 1, 2026

Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, o….

OpenClawNanoClawAnalysisReproductiontooluniverse-drug-drug-interaction🏥 medical & clinicalmedical toolscomprehensive

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-drug-drug-interaction

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
KEY PRINCIPLES: 1. Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively 2. Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ) 3. Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical) 4. Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence 5. Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions 6. Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate.
Ask about interactions between 2+ specific drugs.
Need polypharmacy risk assessment (5+ medications).
Request medication safety review for a patient.

Source Doc

Excerpt From SKILL.md

1. Report-First Approach (MANDATORY)

DO NOT show intermediate tool outputs or search processes. Instead:

Create report file FIRST - Before any data collection:
- File name: DDI_risk_report_[DRUG1]_[DRUG2].md (or _polypharmacy.md for 3+)
- Initialize with all 9 section headers
- Add placeholder: [Analyzing...] in each section
Progressively update - As data is gathered:
- Replace [Analyzing...] with findings
- Include "No interaction detected" when tools return empty
- Document failed tool calls explicitly
Final deliverable - Complete markdown report with recommendations

[... Content continues as above for full 500+ lines ...]

Success Criteria

Before finalizing DDI report:

✅ All drug names resolved to standard identifiers ✅ Bidirectional analysis completed (A→B and B→A) ✅ All mechanism types assessed (CYP, transporters, PD) ✅ FDA label warnings extracted ✅ Clinical literature searched ✅ Evidence grades assigned (★★★, ★★☆, ★☆☆) ✅ Risk score calculated (0-100) ✅ Severity classified (Major/Moderate/Minor) ✅ Primary management recommendation provided ✅ Alternative drugs suggested ✅ Monitoring parameters defined ✅ Patient counseling points included ✅ All sections completed (no [Analyzing...] placeholders) ✅ Data sources cited throughout

When all criteria met → Ready for Clinical Use 🎉