tooluniverse-drug-target-validation

When to Use This Skill

Apply when users:

• Ask "Is [target] a good drug target for [disease]?"
• Need target validation or druggability assessment
• Want to compare targets for drug discovery prioritization
• Ask about safety risks of modulating a target
• Need chemical starting points for target validation
• Ask about pathway context for a target
• Need a GO/NO-GO recommendation for a target
• Want a comprehensive target dossier for investment decisions

NOT for (use other skills instead):

• General target biology overview -> Use tooluniverse-target-research
• Drug compound profiling -> Use tooluniverse-drug-research
• Variant interpretation -> Use tooluniverse-variant-interpretation
• Disease research -> Use tooluniverse-disease-research

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Input Parameters

Parameter	Required	Description	Example
target	Yes	Gene symbol, protein name, or UniProt ID	EGFR, P00533, Epidermal growth factor receptor
disease	No	Disease/indication for context	Non-small cell lung cancer, Pancreatic cancer
modality	No	Preferred therapeutic modality	small molecule, antibody, protein therapeutic, PROTAC

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Score Components (Total: 0-100)

Disease Association (0-30 points):

• Genetic evidence: 0-10 (GWAS, rare variants, somatic mutations)
• Literature evidence: 0-10 (publications, clinical studies)
• Pathway evidence: 0-10 (disease pathway involvement)

Druggability (0-25 points):

• Structural tractability: 0-10 (structure quality, binding pockets)
• Chemical matter: 0-10 (known compounds, bioactivity data)
• Target class: 0-5 (validated target family bonus)

Safety Profile (0-20 points):

• Tissue expression selectivity: 0-5 (expression in critical tissues)
• Genetic validation: 0-10 (knockout phenotypes, human genetics)
• Known adverse events: 0-5 (safety signals from modulators)

Clinical Precedent (0-15 points):

• Approved drugs: 15 (strong precedent, validated target)
• Clinical trials: 10 (moderate precedent)
• Preclinical compounds: 5 (weak precedent)
• None: 0 (novel target)

Validation Evidence (0-10 points):

• Functional studies: 0-5 (CRISPR, siRNA, biochemical)
• Disease models: 0-5 (animal models, patient data)