Data & ReproDrug Discovery & CheminformaticsFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

tooluniverse-network-pharmacology

Maintainer FreedomIntelligence · Last updated April 1, 2026

Construct and analyze compound-target-disease networks for drug repurposing, polypharmacology discovery, and systems pharmacology. Builds multi-layer networks from ChEMBL, OpenTargets, STRING, DrugBank, Reactome, FAERS, and 60+ other ToolUniverse tools. Calculates Network Pharmacology Scores (0-100), identifies repurposing candidates, predicts mechanisms, and analyzes polypharmacology. Use when users ask about drug….

OpenClawNanoClawAnalysisReproductiontooluniverse-network-pharmacology🏥 medical & clinicalmedical toolsconstruct

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-network-pharmacology

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

Construct and analyze compound-target-disease (C-T-D) networks to identify drug repurposing opportunities, understand polypharmacology, and predict drug mechanisms using systems pharmacology approaches.
IMPORTANT: Always use English terms in tool calls (drug names, disease names, target names), even if the user writes in another language. Only try original-language terms as a fallback if English returns no results. Respond in the user's language.
report_path = "[entity]_network_pharmacology_report.md.

Source Doc

Excerpt From SKILL.md

When to Use This Skill

Apply when users:

Ask "Can [drug] be repurposed for [disease] based on network analysis?"
Want to understand multi-target (polypharmacology) effects of a compound
Need compound-target-disease network construction and analysis
Ask about network proximity between drug targets and disease genes
Want systems pharmacology analysis of a drug or target
Ask about drug repurposing candidates ranked by network metrics
Need mechanism prediction for a drug in a new indication
Want to identify hub genes in disease networks as therapeutic targets
Ask about disease module coverage by a compound's targets

NOT for (use other skills instead):

Simple drug repurposing without network analysis -> Use tooluniverse-drug-repurposing
Single target validation -> Use tooluniverse-drug-target-validation
Adverse event detection only -> Use tooluniverse-adverse-event-detection
General disease research -> Use tooluniverse-disease-research
GWAS interpretation -> Use tooluniverse-gwas-snp-interpretation

Input Parameters

Parameter	Required	Description	Example
entity	Yes	Compound name/ID, target gene symbol/ID, or disease name/ID	`metformin`, `EGFR`, `Alzheimer disease`
entity_type	No	Type hint: `compound`, `target`, or `disease` (auto-detected if omitted)	`compound`
analysis_mode	No	`compound-to-disease`, `disease-to-compound`, `target-centric`, `bidirectional` (default)	`bidirectional`
secondary_entity	No	Second entity for focused analysis (e.g., disease for compound input)	`Alzheimer disease`