AR
Data & Repro
arxiv-database
This skill provides Python tools for searching and retrieving preprints from arXiv.org via its public Atom API. It supports keyword search,…
K-Dense-AI/claude-scientific-skillsView
Data & Repro
TO
tooluniverse-polygenic-risk-score
Maintainer FreedomIntelligence · Last updated April 1, 2026
**Use Cases:** - "Calculate my genetic risk for type 2 diabetes" - "Build a polygenic risk score for coronary artery disease" - "What's my genetic predisposition to Al.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-polygenic-risk-score
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data.
- Calculate my genetic risk for type 2 diabetes.
- Build a polygenic risk score for coronary artery disease.
- What's my genetic predisposition to Alzheimer's disease?
- Interpret my PRS percentile for breast cancer risk.
Source Doc
Excerpt From SKILL.md
PRS Calculation Formula
A polygenic risk score is calculated as a weighted sum across genetic variants:
Where:
- dosage_i: Number of effect alleles at SNP i (0, 1, or 2)
- effect_size_i: Beta coefficient or log(odds ratio) from GWAS
Standardization
Raw PRS is standardized to z-scores for interpretation:
This allows comparison to population distribution and percentile calculation.
Significance Thresholds
- Genome-wide significance: p < 5×10⁻⁸ (default threshold)
- This corrects for ~1 million independent tests across the genome
- Relaxed thresholds (e.g., p < 1×10⁻⁵) can include more SNPs but may add noise
Use cases
- Use when asked to calculate polygenic risk scores, interpret genetic risk for complex diseases, build custom PRS from GWAS data, or answer questions like "What is my genetic predisposition to breast cancer?".
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Related skills
Related skills
BA
Data & Repro
bayesian-optimizer
Bayesian optimization for experimental design and hyperparameter tuning in biomedical research.
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-alignment-files-bam-statistics
Compute alignment statistics: flagstat, idxstats, coverage depth.
FreedomIntelligence/OpenClaw-Medical-SkillsView
BI
Data & Repro
bio-alignment-msa-statistics
Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when com…
FreedomIntelligence/OpenClaw-Medical-SkillsView