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varCADD

Maintainer FreedomIntelligence · Last updated April 1, 2026

varCADD.

OpenClawNanoClawAnalysisReproductionvarcaddopenclaw medical skillsadditional scientific toolsvarcadd

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/varCADD

Maintainer
FreedomIntelligence
License
MIT
Last updated
April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

  • Genome-wide pathogenicity prediction leveraging standing variation data to improve accuracy over traditional CADD scores.
  • Variant Prioritization: Ranking candidate variants in rare disease cases.
  • VUS Interpretation: Assessing variants of uncertain significance.
  • Research: Annotating novel variants in population studies.
  • Variant Prioritization: Ranking candidate variants in rare disease cases. VUS Interpretation: Assessing variants of uncertain significance. * Research: Annotating novel variants in population studies.

Source Doc

Excerpt From SKILL.md

Core Capabilities

  1. Score Generation: Calculate C-scores for SNVs and indels.
  2. Annotation: Add functional context (conservation, protein domains).
  3. Filtering: Identify likely pathogenic variants based on thresholds.

Workflow

  1. Input: VCF file.
  2. Annotate: Run varCADD model.
  3. Filter: Keep variants with Score > X.
  4. Output: Annotated VCF or ranked table.

Example Usage

User: "Score these variants from patient X."

Agent Action:

Use cases

  • Use varCADD in research workflows aligned with this subject area.
  • Follow the upstream documentation for the full working procedure.

Not for

  • Do not rely on this catalog entry alone for installation or maintenance details.

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