Data & ReproDrug Discovery & CheminformaticsFreedomIntelligence/OpenClaw-Medical-SkillsData & Reproduction

variant-interpretation-acmg

Maintainer FreedomIntelligence · Last updated April 1, 2026

ACMG/AMP variant interpretation with evidence-based classification framework.

OpenClawNanoClawAnalysisReproductionvariant-interpretation-acmg🧠 bioos extended suitedrug discovery & designacmg

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/variant-interpretation-acmg

Skill Snapshot

2 min

The Variant Interpretation Skill automates the classification of genetic variants (Pathogenic, Benign, VUS) using a rules-based engine derived from ACMG guidelines.
When analyzing a VCF file for clinical reporting.
To determine the clinical significance of a specific mutation (e.g., BRCA1 c.123A>G).
To aggregate evidence (population freq, computational predictions) into a final verdict.
When analyzing a VCF file for clinical reporting. To determine the clinical significance of a specific mutation (e.g., BRCA1 c.123A>G). * To aggregate evidence (population freq, computational predictions) into a final verdict.

Source Doc

Rule Scoring: Applies codes like PVS1 (Null variant), PM2 (Rare), PP3 (In silico).
Classification: Combines scores to reach a verdict (Pathogenic, Likely Pathogenic, VUS, etc.).
Explanation: Provides the logic/evidence used for the classification.

Input: Variant details (Gene, HGVS, Consequence) or Evidence codes directly.
Process: Sums weights of applied ACMG criteria.
Output: Final classification and score breakdown.

User: "Classify a variant with evidence PVS1 and PM2."

Agent Action:

Use variant-interpretation-acmg for medicinal chemistry and drug-discovery work.
Apply variant-interpretation-acmg to compound, target, or screening workflows.

Do not rely on this catalog entry alone for installation or maintenance details.

Related skills

Data & ReproDrug Discovery & Cheminformatics

AAV vector design: capsid selection, promoter optimization, payload capacity.

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView

Data & ReproDrug Discovery & Cheminformatics

AgentD autonomous drug discovery: target identification, hit finding, ADMET optimization.

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView

Data & ReproDrug Discovery & Cheminformatics

Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for tr…

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView

Data & ReproDrug Discovery & Cheminformatics

Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response fr…

OpenClawNanoClawAnalysis

FreedomIntelligence/OpenClaw-Medical-SkillsView