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vcf-basics

Maintainer FreedomIntelligence · Last updated April 1, 2026

vcf-basics.

OpenClawNanoClawAnalysisReproductionvcf-basicsopenclaw medical skillsadditional scientific toolsvcf

Original source

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/vcf-basics

Maintainer: FreedomIntelligence
License: MIT
Last updated: April 1, 2026

Skill Snapshot

Key Details From SKILL.md

2 min

Key Notes

View and query variant files using bcftools and cyvcf2.
bcftools index -t input.vcf.gz.

Source Doc

Excerpt From SKILL.md

Format Overview

Format	Description	Use Case
VCF	Text format, human-readable	Debugging, small files
VCF.gz	Compressed VCF (bgzip)	Standard distribution
BCF	Binary VCF	Fast processing, large files

Header Lines (##)

##fileformat - VCF version
##INFO - INFO field definitions
##FORMAT - FORMAT field definitions
##FILTER - Filter definitions
##contig - Reference contigs
##reference - Reference genome

Column Header (#CHROM)

Fixed columns: CHROM, POS, ID, REF, ALT, QUAL, FILTER, INFO, FORMAT Followed by sample columns

Use cases

Use vcf-basics for genomics and bioinformatics workflows.
Apply vcf-basics to sequencing, variant, or omics analysis tasks.

Not for

Do not rely on this catalog entry alone for installation or maintenance details.

Upstream Related Skills

variant-calling - Generate VCF from alignments
filtering-best-practices - Filter variants by quality/criteria
vcf-manipulation - Merge, concat, intersect VCFs
alignment-files/pileup-generation - Generate pileup for calling

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