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FreedomIntelligence/OpenClaw-Medical-SkillsView
Data & Repro
VC
vcf-manipulation
Maintainer FreedomIntelligence · Last updated April 1, 2026
vcf-manipulation.
Original source
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/vcf-manipulation
- Maintainer
- FreedomIntelligence
- License
- MIT
- Last updated
- April 1, 2026
Skill Snapshot
Key Details From SKILL.md
Key Notes
- Merge, concat, sort, and compare VCF files using bcftools.
- bcftools merge -l files.txt -Oz -o merged.vcf.gz.
Source Doc
Excerpt From SKILL.md
Operations Overview
| Operation | Command | Use Case |
|---|---|---|
| Merge | bcftools merge | Combine samples from multiple VCFs |
| Concat | bcftools concat | Combine regions from multiple VCFs |
| Sort | bcftools sort | Sort unsorted VCF |
| Intersect | bcftools isec | Compare/intersect call sets |
| Subset | bcftools view | Extract samples or regions |
bcftools merge
Combine multiple VCF files with different samples at the same positions.
Output missing genotypes as ./. (default)
bcftools merge sample1.vcf.gz sample2.vcf.gz -Oz -o merged.vcf.gz
Use cases
- Use vcf-manipulation for genomics and bioinformatics workflows.
- Apply vcf-manipulation to sequencing, variant, or omics analysis tasks.
Not for
- Do not rely on this catalog entry alone for installation or maintenance details.
Upstream Related Skills
- vcf-basics - View and query VCF files
- filtering-best-practices - Filter variants before manipulation
- variant-normalization - Normalize before comparing
- vcf-statistics - Compare statistics after manipulation
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