AR
数据与复现
arxiv-search
Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic sea…
FreedomIntelligence/OpenClaw-Medical-Skills查看
数据与复现
AR
armored-cart-design-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Design armored CAR-T cells with cytokine payloads and resistance mechanisms.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/armored-cart-design-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Armored CAR-T Design Agent provides AI-assisted design of next-generation armored CAR-T cells engineered to express cytokines，chemokines，或 other enhancing factors. These armored T cells overcome solid tumor challenges ，涵盖 immunosuppressive TME，poor trafficking，、 T cell exhaustion，，支持 recent clinical success in lymphoma (IL-18) 、 ongoing trials ，支持 IL-12，IL-15，、 IL-7。
- When designing CAR-T cells ，用于 solid tumor applications。
- 用于 selecting optimal armoring payloads (cytokines，chemokines)。
- To optimize cytokine expression levels 、 regulation。
- When engineering safety switches ，用于 armored constructs。
原始文档
SKILL.md 摘录
Core Capabilities
-
Armoring Payload Selection: Choose optimal cytokines for tumor type.
-
Expression Level Optimization: Balance efficacy vs toxicity.
-
Inducible System Design: Engineer regulated expression systems.
-
Safety Switch Integration: Design kill switches and controls.
-
Construct Optimization: Optimize transgene configuration.
-
Efficacy Prediction: Predict enhanced tumor killing.
Armoring Strategies
| Cytokine | Mechanism | Clinical Status | Tumor Types |
|---|---|---|---|
| IL-12 | Th1 polarization, IFN-gamma | Phase I/II | Solid tumors |
| IL-15 | T/NK persistence | Phase I/II | Hematologic, solid |
| IL-18 | Inflammasome, IFN-gamma | Phase I (promising) | Lymphoma |
| IL-7 | T cell survival | Phase I | Multiple |
| IL-21 | T cell proliferation | Preclinical | Multiple |
| CCL19/21 | T cell trafficking | Preclinical | Solid tumors |
Construct Architecture Options
| Component | Options | Consideration |
|---|---|---|
| Promoter | EF1a, PGK, CAG, NFAT-inducible | Expression level/timing |
| Signal Peptide | Native, IL-2ss, IgK | Secretion efficiency |
| Cytokine | Membrane-bound vs secreted | Local vs systemic |
| Linker | T2A, P2A, IRES | Co-expression efficiency |
| Kill Switch | iCasp9, HSV-TK, CD20 | Safety control |
| Position | Before/after CAR | Expression balance |
适用场景
- When designing CAR-T cells ，用于 solid tumor applications。
- 用于 selecting optimal armoring payloads (cytokines，chemokines)。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- CART_Design_Optimizer_Agent - Base CAR optimization
- NK_Cell_Therapy_Agent - NK cell engineering
- Cytokine_Storm_Analysis_Agent - Safety analysis
- TCell_Exhaustion_Analysis_Agent - Exhaustion prevention
相关技能
相关技能
AU
Autonomous oncology research agent: literature mining, trial matching, biomarker analysis, and treatment hypothesis gene…
FreedomIntelligence/OpenClaw-Medical-Skills查看
BI
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-…
FreedomIntelligence/OpenClaw-Medical-Skills查看
BI
Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity gene…
FreedomIntelligence/OpenClaw-Medical-Skills查看