AD
数据与复现
Adaptyv
Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein s…
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数据与复现
BI
binder-design
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/binder-design
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Trim to binding region + 10A buffer。
- Remove waters 、 ligands。
- Renumber chains if needed。
- Trim to binding region + 10A buffer Remove waters 、 ligands Renumber chains if needed。
- modal run modal_rfdiffusion.py \ --pdb target.pdb \ --contigs "A1-150/0 70-100" \ --hotspot "A45，A67，A89" \ --num-designs 500。
原始文档
SKILL.md 摘录
Tool comparison
| Tool | Strengths | Weaknesses | Best For |
|---|---|---|---|
| BoltzGen | All-atom, single-step, ligand-aware | Higher GPU requirement | Standard (recommended) |
| BindCraft | End-to-end, built-in AF2 validation | Less diverse | Production campaigns |
| RFdiffusion | High diversity, fast | Requires ProteinMPNN | Exploration, diversity |
| Germinal | Nanobody/VHH design | Specialized | Antibody optimization |
Recommended Pipeline: BoltzGen → Chai → QC
BoltzGen provides all-atom design with built-in side-chain packing:
2. Hotspot selection
- Choose 3-6 exposed residues
- Prefer charged/aromatic residues
- Cluster spatially (within 10-15A)
适用场景
- Use binder-design in 科研工作流 aligned ，支持 this subject area。
- Follow upstream documentation ，用于 full working procedure。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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