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binding-characterization

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

OpenClawNanoClaw分析处理复现实验binding-characterization🔬 omics & computational biologyprotein structure & designguidance

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/binding-characterization

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

原始文档

SKILL.md 摘录

SPR (Surface Plasmon Resonance)

  • Mechanism: Detects refractive index changes at gold surface
  • Surface: Gold chip with dextran matrix (CM5, CM7, etc.)
  • Flow: Continuous microfluidics
  • Best for: Small molecules, high-affinity, precise kon/koff

BLI (Biolayer Interferometry)

  • Mechanism: Measures optical interference pattern shift
  • Surface: Fiber optic biosensor tips (SA, Ni-NTA, AHC)
  • Flow: Dip-and-read (no microfluidics)
  • Best for: High-throughput, crude samples, antibody screening

Why SPR works but BLI doesn't

CauseMechanismSolution
Small analyteBLI less sensitive for <10 kDaUse SPR with appropriate chip
Weak affinity (KD >10μM)Fast dissociation in BLI dipIncrease analyte concentration
Low expressionNot enough signalIncrease biosensor loading

适用场景

  • 适合在：(1) Planning binding kinetics experiments，(2) Troubleshooting poor/no binding signal，(3) Interpreting kinetic data artifacts，(4) Choosing between SPR vs BLI 平台s时使用。

不适用场景

  • Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

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