AA
AAV vector design: capsid selection, promoter optimization, payload capacity.
FreedomIntelligence/OpenClaw-Medical-Skills查看
数据与复现
BI
bio-clinical-databases-pharmacogenomics
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-pharmacogenomics
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- PM：0。
- IM：0 < score <= 1.25。
- NM：1.25 < score <= 2.25。
- UM：> 2.25 (gene duplications)。
- CYP2D6_ACTIVITY = { '1'：1.0，# Normal function '2'：1.0，# Normal function '3'：0.0，# No function '4'：0.0，# No function '5'：0.0，# Gene deletion '6'：0.0，# No function '9'：0.5，# Decreased function '10'：0.25，# Decreased function (common in East Asian) '17'：0.5，# Decreased function '41'：0.5，# Decreased function }。
原始文档
SKILL.md 摘录
Star Allele Interpretation
Goal: Determine metabolizer phenotype from CYP star allele diplotypes using CPIC activity scores.
Approach: Sum per-allele activity scores and classify into PM/IM/NM/UM categories based on CPIC thresholds.
Drug Interaction Lookup
Goal: Check whether a specific drug-gene-variant combination has a known pharmacogenomic interaction.
Approach: Query PharmGKB variant annotation endpoint filtered by drug and gene, then match to the target variant.
Common PGx Gene-Drug Pairs
| Gene | Drugs | Clinical Impact |
|---|---|---|
| CYP2D6 | Codeine, tamoxifen, ondansetron | Efficacy, toxicity |
| CYP2C19 | Clopidogrel, omeprazole, escitalopram | Efficacy, dosing |
| CYP2C9 | Warfarin, phenytoin, NSAIDs | Bleeding risk, dosing |
| VKORC1 | Warfarin | Dosing |
| TPMT | Azathioprine, mercaptopurine | Myelosuppression |
| DPYD | Fluorouracil, capecitabine | Severe toxicity |
| HLA-B*57:01 | Abacavir | Hypersensitivity |
| HLA-B*15:02 | Carbamazepine | SJS/TEN |
| SLCO1B1 | Simvastatin | Myopathy risk |
| UGT1A1 | Irinotecan | Neutropenia |
适用场景
- 适合在predicting drug response ，面向 genetic variants 或 implementing clinical pharmacogenomics时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- clinical-databases/clinvar-lookup - Pathogenicity classification
- variant-calling/clinical-interpretation - ACMG guidelines
- clinical-databases/variant-prioritization - Clinical filtering
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