数据与复现生物信息与基因组学FreedomIntelligence/OpenClaw-Medical-Skills数据与复现
BI

bio-clip-seq-clip-peak-calling

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Call RBP binding peaks from CLIP-seq with PureCLIP or MACS2.

OpenClawNanoClaw分析处理复现实验bio-clip-seq-clip-peak-calling🧠 bioos extended suitebioos extended bioinformatics suitecall

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clip-seq-clip-peak-calling

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • clipper \ -b deduped.bam \ -s hg38 \ -o peaks.bed \ --save-pickle。
  • clipper \ -b deduped.bam \ -s hg38 \ -o peaks.bed \ --FDR 0.05 \ --superlocal。

原始文档

SKILL.md 摘录

Specify gene annotations

clipper
-b deduped.bam
-s hg38
--gene genes.bed
-o peaks.bed


## CLIPper Options

| Option | Description |
|--------|-------------|
| -b | Input BAM file |
| -s | Species (hg38, mm10) |
| -o | Output BED file |
| --FDR | FDR threshold (default 0.05) |
| --superlocal | Use superlocal background |
| --gene | Custom gene annotation BED |
| --save-pickle | Save intermediate data |

## PureCLIP (HMM-Based)

PureCLIP uses an HMM to model crosslink sites, incorporating enrichment and truncation signals.

```bash

适用场景

  • Use bio-clip-seq-clip-peak-calling ,用于 genomics 、 bioinformatics workflows。
  • Apply bio-clip-seq-clip-peak-calling to sequencing,variant,或 omics analysis tasks。

不适用场景

  • Do not rely on this catalog entry alone ,用于 installation 或 maintenance details。

上游相关技能

  • clip-alignment - Generate aligned BAM
  • clip-preprocessing - UMI deduplication
  • binding-site-annotation - Annotate peaks with gene features
  • clip-motif-analysis - Find enriched motifs in peaks

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