AR
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bio-crispr-screens-batch-correction
维护者 FreedomIntelligence · 最近更新 2026年4月1日
bio-crispr-screens-batch-correction：Batch effect correction ，用于 CRISPR screens。 Covers normalization across batches，technical replicate handling，、 batch-aware analysis。 适合在combining screens ，面向 multiple batches 或 correcting systematic technical variation时使用。
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-crispr-screens-batch-correction
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Python：scipy/sklearn ，用于 median normalization 、 batch correction。
- CLI：mageck test ，支持 batch-aware design。
- Correct batch effects in my CRISPR screens" → Normalize 、 harmonize sgRNA count data across screen batches to remove systematic technical variation while preserving biological signal. Python：scipy/sklearn ，用于 median normalization 、 batch correction CLI：mageck test ，支持 batch-aware design。
- Goal：Remove systematic 库-size differences between batches。
- Approach：Scale each sample within batch so that sample medians match global median，correcting ，用于 sequencing depth variation。
原始文档
SKILL.md 摘录
Batch Effect Removal with ComBat
Goal: Remove batch effects using empirical Bayes adjustment while preserving biological signal.
Approach: Log-transform counts, apply pyCombat with a batch vector, and back-transform to count space.
Batch QC Metrics
Goal: Quantify batch effect magnitude to determine whether correction is needed.
Approach: Run PCA on log-transformed counts, compute between-batch vs within-batch variance ratio, and assess whether batch structure dominates the first principal components.
适用场景
- 适合在combining screens ，面向 multiple batches 或 correcting systematic technical variation时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- mageck-analysis - Batch-aware MAGeCK analysis
- screen-qc - Quality control before correction
- hit-calling - Analysis after batch correction
- library-design - Control guide design
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