数据与复现生物信息与基因组学FreedomIntelligence/OpenClaw-Medical-Skills数据与复现
BI

bio-epitranscriptomics-m6a-differential

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Differential m6A methylation analysis between conditions.

OpenClawNanoClaw分析处理复现实验bio-epitranscriptomics-m6a-differential🧠 bioos extended suitebioos extended bioinformatics suitedifferential

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-epitranscriptomics-m6a-differential

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • design <- data.frame( condition = factor(c('ctrl','ctrl','treat','treat')) )。
  • result <- exomePeak2( bam_ip = c('ctrl_IP1.bam','ctrl_IP2.bam','treat_IP1.bam','treat_IP2.bam'),bam_input = c('ctrl_Input1.bam','ctrl_Input2.bam','treat_Input1.bam','treat_Input2.bam'),gff = 'genes.gtf',genome = 'hg38',experiment_design = design )。

原始文档

SKILL.md 摘录

exomePeak2 Differential Analysis

library(exomePeak2)

## Get differential sites

diff_sites <- results(result, contrast = c('condition', 'treat', 'ctrl'))

IP and input counts per sample

qnb_result <- qnbtest( IP_count_matrix, Input_count_matrix, group = c(1, 1, 2, 2) # 1=ctrl, 2=treat )

适用场景

  • Use bio-epitranscriptomics-m6a-differential ,用于 genomics 、 bioinformatics workflows。
  • Apply bio-epitranscriptomics-m6a-differential to sequencing,variant,或 omics analysis tasks。

不适用场景

  • Do not rely on this catalog entry alone ,用于 installation 或 maintenance details。

上游相关技能

  • m6a-peak-calling - Identify peaks first
  • differential-expression/de-results - Similar statistical concepts
  • modification-visualization - Plot differential sites

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